Breast and Ovarian Cancer: The Genetic Link. Breast and ovarian cancers affect different organs but often share biological roots—especially through genetics. Knowing this link helps with prevention, screening, and treatment.
Shared Genetic Risks
Mutations in BRCA1 and BRCA2 genes, which normally repair DNA, greatly increase risk:
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BRCA1: up to 72% breast cancer risk, 44% ovarian cancer risk
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BRCA2: up to 69% breast cancer risk, 17% ovarian cancer risk
These mutations can be inherited from either parent, making family history critical.
Family History
A mother, sister, or grandmother with breast or ovarian cancer raises your own risk—even if only one type is present. Genetic counseling and testing can guide screening and prevention.
Other Risk Factors
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Age: Risk rises after 50
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Hormone therapy: Long-term HRT may increase risk
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Reproductive history: Early menstruation, late menopause, or never having children raise risk, especially for ovarian cancer
Why It Matters
Recognizing the breast–ovarian cancer connection allows for:
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Early genetic testing
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Personalized screening
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Preventive strategies
